Blar i NTNU Open på forfatter "Gustafsson, Robert"
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MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP
Jemth, Ann-Sofie; Gustafsson, Robert; Bräutigam, Lars; Henriksson, Linda; Vallin, Karl S.A.; Sarno, Antonio; Almlöf, Ingrid; Homan, Evert; Rasti, Azita; Warpman Berglund, Ulrika; Stenmark, Pål; Helleday, Thomas (Journal article; Peer reviewed, 2018)Nucleotides in the free pool are more susceptible to nonenzymatic methylation than those protected in the DNA double helix. Methylated nucleotides like O6-methyl-dGTP can be mutagenic and toxic if incorporated into DNA. ...